Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.

doi:10.18632/oncotarget.3267

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Article

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.

Oncotarget - 20 Apr 2015

Casimiro Mathew C, Di Sante Gabriele, Crosariol Marco, Loro Emanuele, Dampier William, Ertel Adam, Yu Zuoren, Saria Elizabeth A, Papanikolaou Alexandros, Li Zhiping, Wang Chenguang, Addya Sankar, Lisanti Michael P, Fortina Paolo, Cardiff Robert D, Tozeren Aydin, Knudsen Erik S, Arnold Andrew, Pestell Richard G

Abstract excerpt

Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Currently, pharmaceutical initiatives to inhibit cyclin D1 are focused on the catalytic component since the transforming capacity is thought to reside in the cyclin D1/CDK activity. We initiated the following study to directly...

Topics

Adenocarcinoma
Amino Acid Substitution
Aneuploidy
Animals
Catalytic Domain
Cell Transformation, Neoplastic
Cells, Cultured
Centrosome
Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cyclin D1

Female

Fibroblasts

Genes, bcl-1

Humans

Mammary Neoplasms, Experimental

Mammary Tumor Virus, Mouse

Mice

Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 25940700
DOI: 10.18632/oncotarget.3267
PMCID: PMC4496164

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