Article
Cyclins and related kinases in cancer cells.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Sept 2007
Malumbres Marcos
Abstract excerpt
Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key cell cycle molecules that regulate the activity of cyclin-dependent kinases (CDKs). These protein kinases control the progression through the different phases of the cell division cycle. Tumor-associated alterations in their activating partners, cyclins, or in CDK inhibitors help to sustain proliferation with...
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