Article
Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts.
Cell reports - 28 Mar 2017
Golan-Lavi Roni, Giacomelli Chiara, Fuks Garold, Zeisel Amit, Sonntag Johanna, Sinha Sanchari, Köstler Wolfgang, Wiemann Stefan, Korf Ulrike, Yarden Yosef, Domany Eytan
Abstract excerpt
Protein responses to extracellular cues are governed by gene transcription, mRNA degradation and translation, and protein degradation. In order to understand how these time-dependent processes cooperate to generate dynamic responses, we analyzed the response of human mammary cells to the epidermal growth factor (EGF). Integrating time-dependent transcript and protein data into a mathematical model, we inferred...
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