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Article

A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation.

Oncotarget - 6 Oct 2015

Sahni Hemant, Ross Susan, Barbarulo Alessandro, Solanki Anisha, Lau Ching-In, Furmanski Anna, Saldaña José Ignacio, Ono Masahiro, Hubank Mike, Barenco Martino, Crompton Tessa

Abstract excerpt

Developing thymocytes require pre-TCR signalling to differentiate from CD4-CD8- double negative to CD4+CD8+ double positive cell. Here we followed the transcriptional response to pre-TCR signalling in a synchronised population of differentiating double negative thymocytes. This time series analysis revealed a complex transcriptional response, in which thousands of genes were up and down-regulated before changes...

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Identifiers

PMID: 26415229
DOI: 10.18632/oncotarget.5796
PMCID: PMC4745683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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