Article

Impact of protein degradation and cell growth on mammalian proteomes

2025-02-12

Abstract excerpt

Cellular protein abundances are controlled by rates of synthesis and clearance. Since the latter includes protein degradation and dilution due to cell growth, the growth rate may influence the mechanisms controlling variation in protein abundances. To quantify this influence, we analyzed the growth-dependent effects of protein degradation within a cell type (between activated and resting human B-cells), across hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 845979c3-f40e-5994-875a-fa85ce49ac4d
DOI: 10.1101/2025.02.10.637566

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of protein degradation and cell growth on mammalian proteomesDOI 10.1101/2025.02.10.637566Read

The landscape of cellular clearance systems across human tissues and cell types is shaped by tissue-specific proteome needsSemantic proximity Read

Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cellsSemantic proximity Read

Inferring post-transcriptional regulation within and across cell types in human testisSemantic proximity Read

Low cell number proteomic analysis using in-cell protease digests reveals a robust signature for cell cycle state classificationSemantic proximity Read

Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts.Semantic proximity Read

Cell size-dependent mRNA transcription drives proteome remodelingSemantic proximity Read

Quantitative behavior of protein complexes in human cellsSemantic proximity Read

Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiationSemantic proximity Read

Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiationSemantic proximity Read

Systematic differences in protein stability underlie species-specific developmental tempoSemantic proximity Read

Size-scaling promotes senescence-like changes in proteome and organelle contentSemantic proximity Read

Global quantification of mammalian gene expression noiseSemantic proximity Read