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Article

Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2020

Cao Zhixing, Grima Ramon

Abstract excerpt

The stochasticity of gene expression presents significant challenges to the modeling of genetic networks. A two-state model describing promoter switching, transcription, and messenger RNA (mRNA) decay is the standard model of stochastic mRNA dynamics in eukaryotic cells. Here, we extend this model to include mRNA maturation, cell division, gene replication, dosage compensation, and growth-dependent transcription....

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Identifiers

PMID: 32071224
DOI: 10.1073/pnas.1910888117
PMCID: PMC7060679

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