Article

Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression

2022-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Periodic gene expression dynamics are key to cell and organism physiology. Studies of oscillatory expression have focused on networks with intuitive regulatory negative feedback loops, leaving unknown whether other common biochemical reactions can produce oscillations. Oscillation and noise have been proposed to support mammalian progenitor cells’ capacity to restore heterogenous, multimodal exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d9541b6-0182-52b0-b7d9-65c2bcc20fca
DOI: 10.1101/2022.01.12.475956

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expressionDOI 10.1101/2022.01.12.475956Read

From foodwebs to gene regulatory networks (GRNs) - weak repressions by microRNAs confer system stabilitySemantic proximity Read

Impact of competition between precursor and mature microRNAs on stochastic gene expressionSemantic proximity Read

A Feedback Motif that Breaks the Fundamental Limit on Noise Suppression to Stabilize FateSemantic proximity Read

Epigenomics and the concept of degeneracy in biological systems.Semantic proximity Read

Discovery of a Cellular Mechanism Regulating Transcriptional NoiseSemantic proximity Read

Cytoplasmic import and processing of mRNA amplify transcriptional bursts accounting for the majority of cellular noiseSemantic proximity Read

Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells.Semantic proximity Read

Quantitative comparison of single-cell RNA sequencing versus single-molecule RNA imaging for quantifying transcriptional noiseSemantic proximity Read

Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process.Semantic proximity Read

Transcriptional boosting and buffering during neurodevelopment by shifts in mRNA instabilitySemantic proximity Read

A mechanism for robust circadian timekeeping via stoichiometric balance.Semantic proximity Read

Branching and oscillations in the epigenetic landscape of cell-fate determinationSemantic proximity Read