Article
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes.
Genome research - 1 Aug 2003
Yang Edward, van Nimwegen Erik, Zavolan Mihaela, Rajewsky Nikolaus, Schroeder Mark, Magnasco Marcelo, Darnell James E
Abstract excerpt
Although mRNA decay rates are a key determinant of the steady-state concentration for any given mRNA species, relatively little is known, on a population level, about what factors influence turnover rates and how these rates are integrated into cellular decisions. We decided to measure mRNA decay rates in two human cell lines with high-density oligonucleotide arrays that enable the measurement of decay rates...
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