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Article

Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.

Nucleic acids research - 19 May 2017

Manjón Elvira, Edreira Tomás, Muñoz Sofía, Sánchez Yolanda

Abstract excerpt

Rho GTPases are conserved molecules that control cytoskeletal dynamics. These functions are expedited by Rho GEFs that stimulate the release of GDP to enable GTP binding, thereby allowing Rho proteins to initiate intracellular signaling. How Rho GEFs and Rho GTPases protect cells from DNA damage is unknown. Here, we explore the extreme sensitivity of a deletion mutation in the Rho1p exchange factor Rgf1p to the...

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Share to Chromosomes, Fungal
Share to DNA Breaks, Double-Stranded
Share to G2 Phase Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Homologous Recombination

Share to Microbial Viability

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Source

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Identifiers

PMID: 28334931
DOI: 10.1093/nar/gkx176
PMCID: PMC5435928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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