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Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.

Biochemical and biophysical research communications - 31 Dec 2024

Tang Jiashen, Nakamura Mikio, Ng Wai Yee, Feng Naiwen, Ueno Masaru

Abstract excerpt

Homologous recombination is vital for DNA double-strand break repair. Dysfunction in homologous recombination can lead to cell death, mutations, and cancer. In fission yeast (Schizosaccharomyces pombe), RecQ helicase Rqh1 resolves recombination intermediates. We found that rqh1-hd strain impaired growth in media containing hydroxyurea and thiabendazole. Using this condition, we identified a novel pof1 mutation...

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PMID: 39580958
DOI: 10.1016/j.bbrc.2024.151014

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Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.PMID 39580958Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.Semantic proximity Read ↗

Role for the fission yeast RecQ helicase in DNA repair in G2.Semantic proximity Read ↗

Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.Semantic proximity Read ↗

A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.Semantic proximity Read ↗

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Semantic proximity Read ↗

The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.Semantic proximity Read ↗

The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.Semantic proximity Read ↗

Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.Semantic proximity Read ↗

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

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