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Article

Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors.

Annals of surgical oncology - 1 Apr 2010

Chien Wen-Pin, Wong Ruey-Hong, Cheng Ya-Wen, Chen Chih-Yi, Lee Huei

Abstract excerpt

BACKGROUND: Mouse double minute 2 (MDM2) is a negative regulator of p53. In the present study, we examined MDM2 transcriptional activity and messenger RNA (mRNA) expression in lung tumors with respect to MDM2 SNP309 genotypes and p53 mutation status, and the effects of MDM2 SNP309 genotypes and p53 mutation status on lung cancer prognosis. METHODS: p53-null lung cancer cells were cotransfected with MDM2 P2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19941079
DOI: 10.1245/s10434-009-0853-2

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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