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Article

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

17 Mar 2017

Abstract excerpt

Abstract Critical telomere shortening (for example, secondary to partial telomerase deficiency in the rare disease dyskeratosis congenita) causes tissue pathology, but underlying mechanisms are not fully understood. Mice lacking telomerase (for example, mTR−/− telomerase RNA template mutants) provide a model for investigating pathogenesis. In such mice, after several generations of telomerase deficiency telomeres...

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Share to Digestive system and related health
Share to Telomeres, Telomerase, and Senescence
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PMID: 28303901
DOI: 10.1038/ncomms14766

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