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Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

2021-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Telomerase extends chromosome ends in somatic and germline stem cells to ensure continued proliferation. Mutations in genes critical for telomerase function result in telomeropathies such as dyskeratosis congenita (DC), frequently resulting in spontaneous bone marrow failure. While knockout of telomerase in mice has been instrumental in highlighting the importance of telomere length maintenance...

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Literature Corpus work
e5bd64fe-87e8-56b3-916a-6f6dcaa98557
DOI
10.1101/2021.07.29.454392
Open publication

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Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineDOI 10.1101/2021.07.29.454392
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