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Article

Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita.

Cell stem cell - 1 Sept 2016

Woo Dong-Hun, Chen Qijun, Yang Ting-Lin B, Glineburg M Rebecca, Hoge Carla, Leu Nicolae A, Johnson F Brad, Lengner Christopher J

Abstract excerpt

Patients with dyskeratosis congenita (DC) suffer from stem cell failure in highly proliferative tissues, including the intestinal epithelium. Few therapeutic options exist for this disorder, and patients are treated primarily with bone marrow transplantation to restore hematopoietic function. Here, we generate isogenic DC patient and disease allele-corrected intestinal tissue using clustered regularly interspaced...

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Identifiers

PMID: 27545506
DOI: 10.1016/j.stem.2016.05.024
PMCID: PMC7900823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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