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Article

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

Nature - 21 Nov 2013

Florian Maria Carolina, Nattamai Kalpana J, Dörr Karin, Marka Gina, Uberle Bettina, Vas Virag, Eckl Christina, Andrä Immanuel, Schiemann Matthias, Oostendorp Robert A J, Scharffetter-Kochanek Karin, Kestler Hans Armin, Zheng Yi, Geiger Hartmut

Abstract excerpt

Many organs with a high cell turnover (for example, skin, intestine and blood) are composed of short-lived cells that require continuous replenishment by somatic stem cells. Ageing results in the inability of these tissues to maintain homeostasis and it is believed that somatic stem-cell ageing is one underlying cause of tissue attrition with age or age-related diseases. Ageing of haematopoietic stem cells (HSCs)...

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Identifiers

PMID: 24141946
DOI: 10.1038/nature12631
PMCID: PMC4078992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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