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Article

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Nature - 6 Jan 2011

Jaskelioff Mariela, Muller Florian L, Paik Ji-Hye, Thomas Emily, Jiang Shan, Adams Andrew C, Sahin Ergun, Kost-Alimova Maria, Protopopov Alexei, Cadiñanos Juan, Horner James W, Maratos-Flier Eleftheria, Depinho Ronald A

Abstract excerpt

An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigators include progressively damaged genomes. Telomerase-deficient mice have served as a model system...

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Identifiers

PMID: 21113150
DOI: 10.1038/nature09603
PMCID: PMC3057569

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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