Article
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
Cell - 16 Dec 2005
Hao Ling-Yang, Armanios Mary, Strong Margaret A, Karim Baktiar, Feldser David M, Huso David, Greider Carol W
Abstract excerpt
Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating that limiting telomerase compromises telomere maintenance. In later-generation heterozygotes, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.