Article

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

2020-10-28

Abstract excerpt

<h4>Summary</h4> Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to derive from epithelial failure, particularly that of type II alveolar epithelial (AT2) cells, which are highly dependent on Wnt signaling during deve...

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Literature Corpus work: 86e07181-3b78-5551-8c56-f62ab9b650b9
DOI: 10.1101/2020.10.28.358887

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