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Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling

13 Sept 2019

Abstract excerpt

Telomere shortening is associated with aging and age-associated diseases.Additionally, telomere dysfunction resulting from telomerase gene mutation can lead to premature aging, such as apparent skin atrophy and hair loss.However, the molecular signaling linking telomere dysfunction to skin atrophy remains elusive.Here we show that dysfunctional telomere disrupts BMP/pSmad/P63 signaling, impairing epidermal stem...

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PMID: 31518356
DOI: 10.1371/journal.pgen.1008368

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