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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.

Molecular and cellular biology - 1 Jun 2011

Strong Margaret A, Vidal-Cardenas Sofia L, Karim Baktiar, Yu Huimin, Guo Nini, Greider Carol W

Abstract excerpt

Telomerase is essential for telomere length maintenance. Mutations in either of the two core components of telomerase, telomerase RNA (TR) or the catalytic protein component telomerase reverse transcriptase (TERT), cause the genetic disorders dyskeratosis congenita, pulmonary fibrosis, and other degenerative diseases. Overexpression of the TERT protein has been reported to have telomere length-independent roles,...

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Identifiers

PMID: 21464209
DOI: 10.1128/MCB.05312-11
PMCID: PMC3133422

Genes

TERT
CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.PMID 21464209Read ↗

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