Article
Molecular map of chronic lymphocytic leukemia and its impact on outcome.
Nature genetics - 1 Nov 2022
Knisbacher Binyamin A, Lin Ziao, Hahn Cynthia K, Nadeu Ferran, Duran-Ferrer Martí, Stevenson Kristen E, Tausch Eugen, Delgado Julio, Barbera-Mourelle Alex, Taylor-Weiner Amaro, Bousquets-Muñoz Pablo, Diaz-Navarro Ander, Dunford Andrew, Anand Shankara, Kretzmer Helene, Gutierrez-Abril Jesus, López-Tamargo Sara, Fernandes Stacey M, Sun Clare, Sivina Mariela, Rassenti Laura Z, Schneider Christof, Li Shuqiang, Parida Laxmi, Meissner Alexander, Aguet François, Burger Jan A, Wiestner Adrian, Kipps Thomas J, Brown Jennifer R, Hallek Michael, Stewart Chip, Neuberg Donna S, Martín-Subero José I, Puente Xose S, Stilgenbauer Stephan, Wu Catherine J, Campo Elias, Getz Gad
Abstract excerpt
Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymphocytic leukemia (CLL), a B cell neoplasm with variable natural history that is conventionally categorized into two subtypes distinguished by extent of somatic mutations in the heavy-chain variable region of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.