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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

2020-02-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic alterations that are acquired during tumor initiation and progression. The precise dissec...

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Literature Corpus work
b3ecfc60-569d-54be-9e78-ff5c8b91e06b
DOI
10.1101/2020.02.04.933937
Open publication

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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLLDOI 10.1101/2020.02.04.933937
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