Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

Abstract excerpt

Atherosclerotic plaque rupture with subsequent embolic events is a major cause of sudden death from myocardial infarction or stroke. Although smooth muscle cells (SMCs) produce and respond to collagens in vitro, there is no direct evidence in vivo that SMCs are a crucial source of collagens and that this impacts lesion development or fibrous cap formation. We sought to determine how conditional SMC-specific...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Atherosclerosis and Cardiovascular Diseases
• Share to Cell Adhesion Molecules Research
• Share to Coronary Interventions and Diagnostics