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Article

Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis

2 Aug 2013

Abstract excerpt

Smooth muscle cell (SMC) proliferation is a hallmark of vascular injury and disease. Global hypomethylation occurs during SMC proliferation in culture and in vivo during neointimal formation. Regardless of the programmed or stochastic nature of hypomethylation, identifying these changes is important in understanding vascular disease, as maintenance of a cells' epigenetic profile is essential for maintaining...

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PMID: 23912340
DOI: 10.1093/hmg/ddt365

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