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Article

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2017

Zhang Xiaoyan, Li Sha, Zhou Yunfeng, Su Wen, Ruan Xiongzhong, Wang Bing, Zheng Feng, Warner Margaret, Gustafsson Jan-Åke, Guan Youfei

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is characterized by simple hepatic steatosis (SS), nonalcoholic steatohepatitis (NASH), hepatic fibrosis, and cirrhosis. Dysregulated fatty acid metabolism in the liver plays a critical role in the pathogenesis of NAFLD. Cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) is a homolog of human CYP4A hydroxylase that catalyzes omega-hydroxylation of medium-chain fatty acids...

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Identifiers

PMID: 28270609
DOI: 10.1073/pnas.1700172114
PMCID: PMC5373383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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