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Article

Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice.

International immunopharmacology - 1 Jan 2021

Wang Yinan, Yang Ziyu, Wei Yang, Li Xiaoming, Li Shengbin

Abstract excerpt

This article explores the role of ApoA4 in a CCl4-induced chronic liver injury (CLI) mouse model. C57BL/6J mice (WT) and ApoA4 knock-out (KO) mice were divided into CCl4 CLI (WT-CCl4 and KO-CCl4) and olive oil solvent control groups (WT-Veh and KO-Veh). Some of the KO-CCl4 mice were additionally treated with recombinant mouse ApoA4 and primary mouse T lymphocyte injections. After 6 weeks, histological analyses,...

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Identifiers

PMID: 33276196
DOI: 10.1016/j.intimp.2020.107222

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