Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.

doi:10.1016/j.cmet.2012.04.004

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Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.

Cell metabolism - 2 May 2012

Min Hae-Ki, Kapoor Ashwani, Fuchs Michael, Mirshahi Faridoddin, Zhou Huiping, Maher James, Kellum John, Warnick Russell, Contos Melissa J, Sanyal Arun J

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride and free cholesterol (FC) accumulation without a corresponding increment in cholesterol esters. The aim of this study was to evaluate the expression of cholesterol metabolic genes in NAFLD and relate these to disease phenotype. NAFLD was associated with...

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Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.

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