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Article

Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.

Physiological genomics - 11 Feb 2011

Gonzalez Monika, Sealls Whitney, Jesch Elliot D, Brosnan M Julia, Ladunga Istvan, Ding Xinxin, Black Paul N, DiRusso Concetta C

Abstract excerpt

Liver-specific ablation of cytochrome P450 reductase in mice (LCN) results in hepatic steatosis that can progress to steatohepatitis characterized by inflammation and fibrosis. The specific cause of the fatty liver phenotype is poorly understood but is hypothesized to result from elevated express...

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Identifiers

PMID: 21098682
DOI: 10.1152/physiolgenomics.00209.2010
PMCID: PMC3055711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21098682-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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