Article

Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization

2024-06-20

Abstract excerpt

<title>Abstract</title> Nonalcoholic fatty liver disease (NAFLD), a major cause of chronic liver disorders, has become a serious public health issue. Although the Smad4 signaling pathway has been implicated in the progression of NAFLD, the specific role of Smad4 in hepatocytes in NAFLD pathogenesis remains unclear.<bold> </bold>Hepatocyte-specific knockout Smad4 mice (AlbSmad4-/-) were first constru...

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Literature Corpus work: 9bb1b669-e7bf-576e-a7f4-d6eaf5cadef4
DOI: 10.21203/rs.3.rs-4507474/v1

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