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Article

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2011

Csak Timea, Velayudham Arumugam, Hritz Istvan, Petrasek Jan, Levin Ivan, Lippai Dora, Catalano Donna, Mandrekar Pranoti, Dolganiuc Angela, Kurt-Jones Evelyn, Szabo Gyongyi

Abstract excerpt

Toll-like receptor 4 (TLR4) and its coreceptor, myeloid differentiation factor-2 (MD-2), are key in recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways. Here we tested the hypothesis that TLR4 and its coreceptor MD-2 play a central role in nonalcoholic steatohepatitis (NASH) and liver fibrosis in nonalcoholic fatty liver disease. Mice of control genotypes and those deficient in MD-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21233280
DOI: 10.1152/ajpgi.00163.2009
PMCID: PMC3302188

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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