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Article

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

26 May 2021

Abstract excerpt

In response to infection, pathogen-specific CD8 T cells differentiate into functionally diverse effector and memory T cell populations critical for resolving disease and providing durable immunity. Through small-molecule inhibition, RNAi studies, and induced genetic deletion, we reveal an essential role for the chromatin modifier and BET family member BRD4 in supporting the differentiation and maintenance of...

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PMID: 34037670
DOI: 10.1084/jem.20202512

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