Article
Molecular analysis of BRAF V600E mutation in multiple nodules of pulmonary Langerhans cell histiocytosis.
Virchows Archiv : an international journal of pathology - 1 Apr 2017
Dimmler Arno, Geddert Helene, Werner Martin, Faller Gerhard
Abstract excerpt
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking-related histiocytic disorder with variable clinical symptoms. Like in other non-pulmonary Langerhans cell proliferations, PLCH has recently been shown to harbour BRAF V600E mutations in a significant subset of cases, thus challenging the concept of PLCH being a reactive disorder. Here, we analysed 38 formalin-fixed and paraffin-embedded PLCH...
Topics
- Adult
- Aged
- DNA Mutational Analysis
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction