Article
Recurrent BRAF mutations in Langerhans cell histiocytosis.
Blood - 16 Sept 2010
Badalian-Very Gayane, Vergilio Jo-Anne, Degar Barbara A, MacConaill Laura E, Brandner Barbara, Calicchio Monica L, Kuo Frank C, Ligon Azra H, Stevenson Kristen E, Kehoe Sarah M, Garraway Levi A, Hahn William C, Meyerson Matthew, Fleming Mark D, Rollins Barrett J
Abstract excerpt
Langerhans cell histiocytosis (LCH) has a broad spectrum of clinical behaviors; some cases are self-limited, whereas others involve multiple organs and cause significant mortality. Although Langerhans cells in LCH are clonal, their benign morphology and their lack (to date) of reported recurrent genomic abnormalities have suggested that LCH may not be a neoplasm. Here, using 2 orthogonal technologies for...
Topics
- Adolescent
- Adult
- Amino Acid Substitution
- Antigens, CD1
- Child
- Child, Preschool
- DNA Mutational Analysis
- Extracellular Signal-Regulated MAP Kinases
- Female
- Fluorescent Antibody Technique