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Article

Pulmonary Langerhans Cell Histiocytosis: An Update From the Pathologists' Perspective.

Archives of pathology & laboratory medicine - 1 Mar 2016

Roden Anja C, Yi Eunhee S

Abstract excerpt

CONTEXT: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare histiocytic disorder that almost exclusively affects the lungs of smokers. PLCH is characterized by bronchiolocentric nodules and/or cysts in an upper and mid lung distribution with sparing of the costophrenic angles. The diagnosis can be challenging and often requires transbronchial biopsy or surgical lung biopsy. Pulmonary hypertension is a...

Topics

Amino Acid Substitution
Biopsy
Combined Modality Therapy
Diagnosis, Differential
Histiocytosis, Langerhans-Cell
Humans
Hypertension, Pulmonary
Immunohistochemistry
Lung
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Radiography

Respiratory Mucosa

Severity of Illness Index

Smoking Cessation

Source

Identifiers

PMID: 26927717
DOI: 10.5858/arpa.2015-0246-RA

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26927717-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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