Article
Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease.
Histopathology - 1 Sept 2016
Kamionek Michal, Ahmadi Moghaddam Parnian, Sakhdari Ali, Kovach Alexandra E, Welch Matthew, Meng Xiuling, Dresser Karen, Tomaszewicz Keith, Cosar Ediz F, Mark Eugene J, Fraire Armando E, Hutchinson Lloyd
Abstract excerpt
AIMS: Pulmonary Langerhans cell histiocytosis (PLCH) is an idiopathic cigarette smoking-related disorder of the lung. Molecular changes in cellular or fibrotic stages of PLCH have not been investigated. We studied the prevalence of extracellular signal-regulated kinase (ERK) pathway mutations in different PLCH stages and other non-PLCH smoking-related lung diseases. METHODS AND RESULTS: The cohort included 28...
Topics
- Adolescent
- Adult
- Aged
- DNA Mutational Analysis
- Female
- High-Throughput Nucleotide Sequencing
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry