Article
Pulmonary Langerhans cell histiocytosis: profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations.
Chest - 1 Jun 2013
Yousem Samuel A, Dacic Sanja, Nikiforov Yuri E, Nikiforova Marina
Abstract excerpt
BACKGROUND: Pulmonary Langerhans cell histiocytosis is a localized proliferation of Langerhans cells in the lung that presents without systemic manifestations as bilateral nodular lung disease in adult cigarette smokers. The molecular basis for this proliferation is unknown. METHODS: Twenty-two c...
Topics
- Adult
- Aged
- Biopsy
- DNA Mutational Analysis
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf
- Tissue Fixation
- Transcriptome