Article
BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases.
The American journal of surgical pathology - 1 Apr 2014
Roden Anja C, Hu Xiaowen, Kip Sertac, Parrilla Castellar Edgardo R, Rumilla Kandelaria M, Vrana Julie A, Vassallo Robert, Ryu Jay H, Yi Eunhee S
Abstract excerpt
Pulmonary Langerhans cell histiocytosis (PLCH) has been postulated to be a smoking-related non-neoplastic condition, distinct from extrapulmonary LCH, which is generally regarded as a clonal, neoplastic process. Recent genomic studies demonstrated BRAF V600E mutation in 38% to 57% of extrapulmona...
Topics
- Adult
- DNA Mutational Analysis
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Lung Diseases
- Male
- Mutation
- Proto-Oncogene Proteins B-raf
- Smoking