Article
Recurrent NRAS mutations in pulmonary Langerhans cell histiocytosis.
The European respiratory journal - 1 Jun 2016
Mourah Samia, How-Kit Alexandre, Meignin Véronique, Gossot Dominique, Lorillon Gwenaël, Bugnet Emmanuelle, Mauger Florence, Lebbe Celeste, Chevret Sylvie, Tost Jörg, Tazi Abdellatif
Abstract excerpt
The mitogen-activated protein kinase (MAPK) pathway is constantly activated in Langerhans cell histiocytosis (LCH). Mutations of the downstream kinases BRAF and MAP2K1 mediate this activation in a subset of LCH lesions. In this study, we attempted to identify other mutations which may explain the MAPK activation in nonmutated BRAF and MAP2K1 LCH lesions.We analysed 26 pulmonary and 37 nonpulmonary LCH lesions for...
Topics
- Adult
- Biopsy
- Disease Progression
- Female
- Genotype
- Histiocytosis, Langerhans-Cell
- Humans
- Lung
- MAP Kinase Kinase 1
- MAP Kinase Signaling System
- Male