Assessment of BRAFV600E mutation in pulmonary Langerhans cell histiocytosis in tissue biopsies and bronchoalveolar lavages by droplet digital polymerase chain reaction.

doi:10.1007/s00428-017-2185-0

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Article

Assessment of BRAFV600E mutation in pulmonary Langerhans cell histiocytosis in tissue biopsies and bronchoalveolar lavages by droplet digital polymerase chain reaction.

Virchows Archiv : an international journal of pathology - 1 Feb 2018

Pierry Clémence, Caumont Charline, Blanchard Elodie, Brochet Camille, Dournes Gael, Gros Audrey, Bandres Thomas, Verdon Séverine, Marty Marion, Bégueret Hugues, Merlio Jean-Philippe

Abstract excerpt

The neoplastic nature of pulmonary Langerhans cell histiocytosis (PLCH) is still debated. As the detection of BRAF V600E and MAP2K1 mutations in patients with PCLH is now considered for such assessment, the aim of our study was to evaluate digital droplet polymerase chain reaction (ddPCR) in PCLH diagnosis. We retrospectively analyzed BRAFV600E detection in a cohort of 42 PCLH tissues and 18 bronchoalveolar...

Topics

Adult
Biopsy
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid
DNA Mutational Analysis
Female
Genetic Markers
High-Throughput Nucleotide Sequencing
Histiocytosis, Langerhans-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Lung

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Proto-Oncogene Proteins B-raf

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 28711990
DOI: 10.1007/s00428-017-2185-0

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28711990-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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