Article
Langerhans cell histiocytosis associated with lymphoma: an incidental finding that is not associated with BRAF or MAP2K1 mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2017
Pina-Oviedo Sergio, Medeiros L Jeffrey, Li Shaoying, Khoury Joseph D, Patel Keyur P, Alayed Khaled, Cason R Craig, Bowman Christopher J, Yin C Cameron
Abstract excerpt
Langerhans cell histiocytosis is characterized by a localized or systemic proliferation of Langerhans cells. BRAF mutations have been reported in 40-70% of cases and MAP2K1 mutations have been found in BRAF-negative cases, supporting that Langerhans cell histiocytosis is a true neoplasm, at least...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Incidental Findings
- Lymphoma
- MAP Kinase Kinase 1
- Male
- Middle Aged
- Mutation
- Proto-Oncogene Proteins B-raf