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Article

PDI regulates seizure activity via NMDA receptor redox in rats.

Scientific reports - 15 Feb 2017

Kim Ji Yang, Ko Ah-Rhem, Hyun Hye-Won, Min Su-Ji, Kim Ji-Eun

Abstract excerpt

Redox modulation of cysteine residues is one of the post-translational modifications of N-methyl-D-aspartate receptor (NMDAR). Protein disulfide isomerases (PDI), an endoplasmic reticulum (ER) chaperone, plays a crucial role in catalyzing disulfide bond formation, reduction, and isomerization. In the present study, we found that PDI bound to NMDAR in the normal hippocampus, and that this binding was increased in...

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Identifiers

PMID: 28198441
DOI: 10.1038/srep42491
PMCID: PMC5309844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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