Article
Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity.
PloS one - 1 Jan 2012
Wang Shao-Bin, Shi Qi, Xu Yin, Xie Wu-Ling, Zhang Jin, Tian Chan, Guo Yan, Wang Ke, Zhang Bao-Yun, Chen Cao, Gao Chen, Dong Xiao-Ping
Abstract excerpt
BACKGROUND: Protein disulfide isomerase (PDI), is sorted to be enzymatic chaperone for reconstructing misfolded protein in endoplasmic reticulum lumen. Recently, PDI has been identified as a link between misfolded protein and neuron apoptosis. However, the potential for PDI to be involved in the pathogenesis of prion disease remains unknown. In this study, we propose that PDI may function as a pleiotropic...
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