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Article

The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jun 2010

Zhang Ying, Su Ping, Liang Ping, Liu Tao, Liu Xu, Liu Xin-Ying, Zhang Bo, Han Tao, Zhu Yan-Bing, Yin Dong-Min, Li Junfa, Zhou Zhuan, Wang Ke-Wei, Wang Yun

Abstract excerpt

Glutamate-induced excitotoxicity has been implicated in the etiology of stroke, epilepsy, and neurodegenerative diseases. NMDA receptors (NMDARs) play a pivotal role in excitotoxic injury; however, clinical trials testing NMDAR antagonists as neuroprotectants have been discouraging. The development of novel neuroprotectant molecules is being vigorously pursued. Here, we report that downstream regulatory element...

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Identifiers

PMID: 20519532
DOI: 10.1523/JNEUROSCI.1312-10.2010
PMCID: PMC6632380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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