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Article

Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents.

Chemico-biological interactions - 25 Feb 2013

Endo Satoshi, Fujimoto Airi, Kumada Sho, Matsunaga Toshiyuki, Ohno Satoshi, Mano Jun'ichi, Tajima Kazuo, El-Kabbani Ossama, Hara Akira

Abstract excerpt

Rabbit aldo-keto reductase (AKR) 1B19 is an ortholog of human aldose reductase-like protein (ARLP), AKR1B10, showing 86% amino acid sequence identity. AKR1B19 exhibits the highest catalytic efficiency for 4-oxo-2-nonenal, a major product of lipid peroxidation, compared to known reductases of this aldehyde. In this study, we found that the reductase activity of AKR1B19 was activated to about 5-fold immediately...

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PMID: 23261715
DOI: 10.1016/j.cbi.2012.11.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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