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Article

d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.

Neurobiology of aging - 1 May 2015

Cristino Luigia, Luongo Livio, Squillace Marta, Paolone Giovanna, Mango Dalila, Piccinin Sonia, Zianni Elisa, Imperatore Roberta, Iannotta Monica, Longo Francesco, Errico Francesco, Vescovi Angelo Luigi, Morari Michele, Maione Sabatino, Gardoni Fabrizio, Nisticò Robert, Usiello Alessandro

Abstract excerpt

We have investigated the relevance of d-aspartate oxidase, the only enzyme known to selectively degrade d-aspartate (d-Asp), in modulating glutamatergic system homeostasis. Interestingly, the lack of the Ddo gene, by raising d-Asp content, induces a substantial increase in extracellular glutamate (Glu) levels in Ddo-mutant brains. Consistent with an exaggerated and persistent N-methyl-d-aspartate receptor (NMDAR)...

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PMID: 25771393
DOI: 10.1016/j.neurobiolaging.2015.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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