Article

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy

2023-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Epilepsy affects over 65 million people worldwide and significantly burdens patients, caregivers, and society. Drug-resistant epilepsy occurs in approximately 30% of patients and growing evidence indicates that oxidative stress contributes to the development of such epilepsies. Activation of the Nrf2 pathway, which is involved in cellular defense, offers a potent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e8a06ab-0a74-5ee1-bf11-090908a21ad3
DOI: 10.21203/rs.3.rs-3270154/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsyDOI 10.21203/rs.3.rs-3270154/v1Read

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent MechanismsSemantic proximity Read

The Emerging Role of Dimethyl Fumarate in Alzheimer’s Disease—A Systematic Review of Available Preclinical StudiesSemantic proximity Read

Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsySemantic proximity Read

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease.Semantic proximity Read

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.Semantic proximity Read

Genistein Protects Epilepsy-Induced Brain Injury Through Regulating The JAK2/STAT3 and Keap1/Nrf2 Signaling Pathways in The Developing RatsSemantic proximity Read

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments.Semantic proximity Read

Exploring oxidative stress pathways in epilepsySemantic proximity Read

Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice.Semantic proximity Read

Real-world Safety and Efficacy of Dimethyl Fumarate in Relapse-Remitting Multiple Sclerosis Patients: A Regional Cohort Report of the Iranian PatientsSemantic proximity Read

Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L.Semantic proximity Read

The pharmacological manipulation of the Nrf2 pathway and its therapeutic significanceSemantic proximity Read