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Article

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

Brain : a journal of neurology - 1 May 2018

Shekh-Ahmad Tawfeeq, Eckel Ramona, Dayalan Naidu Sharadha, Higgins Maureen, Yamamoto Masayuki, Dinkova-Kostova Albena T, Kovac Stjepana, Abramov Andrey Y, Walker Matthew C

Abstract excerpt

Hippocampal sclerosis is a common acquired disease that is a major cause of drug-resistant epilepsy. A mechanism that has been proposed to lead from brain insult to hippocampal sclerosis is the excessive generation of reactive oxygen species, and consequent mitochondrial failure. Here we use a novel strategy to increase endogenous antioxidant defences using RTA 408, which we show activates nuclear factor...

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Source

Identifiers

PMID: 29538645
DOI: 10.1093/brain/awy071

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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