A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors.

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Article

A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors.

The Journal of pharmacology and experimental therapeutics - 1 Nov 1999

Brimecombe J C, Potthoff W K, Aizenman E

Abstract excerpt

In recombinant N-methyl-D-aspartate (NMDA) receptors, two redox modulatory sites are thought to exist, one formed by Cys744 and Cys798 on NMDA receptor subunit (NR) 1, and a second one, not yet localized, on NR2A. Reductants increase the open dwell-time and opening frequency of NR1/NR2A channels. In contrast, NR1/NR2B and NR1/NR2C channels exhibit changes only in opening frequency after redox treatments. Here, we...

Topics

Animals
Binding Sites
CHO Cells
Cricetinae
Cysteine
Dithionitrobenzoic Acid
Mutation
Oxidation-Reduction
Receptors, N-Methyl-D-Aspartate
Recombinant Proteins
Reducing Agents
Sulfhydryl Reagents
Time Factors
Transfection

Source

Open in PubMed

Identifiers

PMID: 10525101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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