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Article

Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis.

Molecular neurobiology - 1 Apr 2014

Jeon Gye Sun, Nakamura Tomohiro, Lee Jeong-Seon, Choi Won-Jun, Ahn Suk-Won, Lee Kwang-Woo, Sung Jung-Joon, Lipton Stuart A

Abstract excerpt

Aggregation of misfolded protein and resultant intracellular inclusion body formation are common hallmarks of mutant superoxide dismutase (mSOD1)-linked familial amyotrophic lateral sclerosis (FALS) and have been associated with the selective neuronal death. Protein disulfide isomerase (PDI) represents a family of enzymatic chaperones that can fold nascent and aberrant proteins in the endoplasmic reticulum (ER)...

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Identifiers

PMID: 24091828
DOI: 10.1007/s12035-013-8562-z
PMCID: PMC5973792

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis.PMID 24091828Read ↗

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