Article
Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.
Nucleic acids research - 17 Feb 2017
Takikawa Masahiro, Tarumoto Yusuke, Ishikawa Fuyuki
Abstract excerpt
The CST complex is a phylogenetically conserved protein complex consisting of CTC1/Cdc13, Stn1 and Ten1 that protects telomeres on linear chromosomes. Deletion of the fission yeast homologs stn1 and ten1 results in complete telomere loss; however, the precise function of Stn1 is still largely unknown. Here, we have isolated a high-temperature sensitive stn1 allele (termed stn1-1). stn1-1 cells abruptly lost...
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